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@3:16 - 3:19 How would you suggest this be disbursed, aerosols?
VMAT2 encodes a transporter protein that imports several monoamine neurotransmitters into vesicles in the brain (reviewed in Zheng et al.,2006). Thus, an alteration in the transporter could potentially affect the levels of multiple types of neurotransmitters, resulting in altered brain function.
FIG.1
FIG.1
DA is a catecholamine neurotransmitter employed by several major CNS pathways, including the nigrostriatal, mesolimbic, mesocortical, and tuberoinfundibular systems. A canonical model of presynaptic DA terminal form and function is presented in Fig.1. DA production, vesicular localization and release, and extracellular persistence are largely regulated by the coordinated activity of tyrosine hydroxylase (TH), VMAT2, and DAT, respectively.
